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Therefore, modulation of the gut microbiome, possibly by dietary modulation, could be an effective way to alleviate the burden of obesity.
Our laboratory developed a co-culture model of mealworm larvae and probiotics, representing a new pre-clinical model to determine the effects of probiotics on the gut microbiome and the metabolic phenotype in the host. In this study, mealworms were infected with Lactobacillus reuteri or Escherichia coli as a vehicle control , then in a second experiment, probiotic treatment was initiated at an early developmental stage. We found that probiotic treatment initiated in pre-adolescence resulted in a decrease in body mass and increased glucose tolerance, with altered gut bacterial profiles.
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